反应详情

To a solution of 1-[[4-hydroxy-1-(4,5-diphenyloxazol-2-yl)butyl]amino]-2,3-dihydro-4-methoxy-1H-indene (0.27 g) in CH2Cl2 (5 ml) was added SOCl9 (1 ml) at 0° C. After being stirred for 17 hours at room temperature, the solvent was evaporated in vacuo and the residue was dissolved in DMF (5 ml). To the mixture was added K2CO3 (2.07 g). After being stirred for 1 day at room temperature, the mixture was partitioned between ethyl acetate and water. The organic layer was washed with brine. The dried solvent was evaporated in vacuo. The residue was purified by chromatography on silica gel to give 1-[2-(4,5-diphenyloxazol-2-yl)pyrrolidin-1-yl]-2,3-dihydro-4-methoxy-1H-indene (0.15 g). MS (m/z): 437 (M+ +1) NMR (CDCl31 5) 1.42-3.20 (10H, m), 3.74 (2.5H, s), 3.81 (3.5H, s), 4.02-4.76 (2H, m), 6.58-7.72 (13H, m)

1. customthe solvent was evaporated in vacuo
2. dissolutionthe residue was dissolved in DMF (5 ml)
3. additionTo the mixture was added K2CO3 (2.07 g)
4. stirringAfter being stirred for 1 day at room temperature
5. customthe mixture was partitioned between ethyl acetate and water
6. washThe organic layer was washed with brine
7. customThe dried solvent was evaporated in vacuo
8. customThe residue was purified by chromatography on silica gel