Ethyl bromoacetate → HCID 18367297, compound

Participants

Reaction Steps

To a solution of 1-[2-[4,5-bis(4-methylphenyl)oxazol-2-yl]pyrrolidin-1-yl]-1,2,3,4-tetrahydro-5-hydroxynaphthalene (0.13 g) and ethyl bromoacetate (0.10 g) in DMF (5 ml) was added K2CO3 (0.13 g). After being stirred for 2 days at room temperature, the mixture was partitioned between ethyl acetate and water. The organic layer was washed with brine. The dried solvent was evaporated in vacuo. The residue was purified by chromatography on silica gel to give 1-[2-[4,5-bis(4-methylphenyl)oxazol-2-yl]pyrrolidin-1-yl]-1,2,3,4-tetrahydro-5-ethoxycarbonylmethoxynaphthalene (0.13 g). MS (m/z): 551 (M+ +1) NMR (CDCl3, δ): 1.18-1.40 (4H, m), 1.52-2.98 (18H, m), 3.90-4.70 (6H, m), 6.34-7.60 (11H, m)

Provenance & Evidence