HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium cyanoborohydride → 3-[2-(4-Hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl)-ethylamino]-N-[2-(2-phenylthioethoxy)ethyl]propanesulphonamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | Methyl 3-[2-(2-phenylthioethoxy)ethylaminosulphonyl]propanoate | HCID 18779027 | — |
| Reactant | Diisobutylaluminumhydride | HCID 21225700 | — |
| Reactant | 4-Hydroxy-7-(2-aminoethyl)-1,3-benzothiazol-2(3H)-one hydrochloride | HCID 60207553 | — |
| Product | 3-[2-(4-Hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl)-ethylamino]-N-[2-(2-phenylthioethoxy)ethyl]propanesulphonamide hydrochloride | HCID 18779070 | 4.8% |
Reaction Steps
The title compound (0.106 g) was prepared according to the procedure in example 8 part e using methyl 3-[2-(2-phenylthioethoxy)ethylaminosulphonyl]propanoate (1.4 g), diisobutylaluminiumhydride (1.5 M in toluene, 3 ml), 7-(2-aminoethyl)-4-hydroxy-1,3-benzothiazol-2(3H)-one hydrochloride (1.2 g) and sodium cyanoborohydride (0.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05973167 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-3941e0e1f19c4684bca8d2bfec6284f3 |
| Source note | uspto-grants-1999_10 |