1,2-Dichloroethane → HCID 54227758, compound

Participants

Reaction Steps

To a solution of the acid prepared in step F (125 mg, 0.276 mmol), 1-naphthylmethylamine (39 μl, 0.28 mmol), HOBT (38.1 mg, 0.28 mmol), and triethylamine (40.0 μl, 0.29 mmol) in DMF (3.0 ml) at 0° C., was added EDC (53.0 mg, 0.28 mmol). The reaction was stirred at room temperature for 4 hrs, diluted with EtOAc and the organic layer washed with sat. aq NaHCO3, brine and dried (Na2SO4). The solvent was evaporated in vacuo to afford the title compound.

Provenance & Evidence