HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 18660145, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 2,2,2-Trifluoro-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethan-1-one | HCID 18660144 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 18660145 | HCID 18660145 | — |
Reaction Steps
To a solution of the product of step A (1.002 g, 5.08 mmol) and triethylamine (0.78 ml, 5.60 mmol) in CH2Cl2 (50 ml) at -25° C. was added methane sulfonyl chloride (0.40 ml, 5.17 mmol) over a period of 5 min and stirring was continued for 1 hr. The solvent was evaporated in vacuo and the residue purified by chromatography(SiO2, 33% EtOAc in hexanes, elution). The title compound was obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05972984 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-f35831bc33844711b55c5bae2d3545ed |
| Source note | uspto-grants-1999_10 |