Ethanolamine → HCID 14208466, compound

Temperature

100 °C

To 15 ml of toluene, there were added 4.0 g (32.5 mmol) of N-(2-hydroxy-4-methylphenyl)methylcarbamate, 4.58 g (7.50 mmol) of 2-aminoethanol and 1.93 g (35.8 mmol) of sodium methoxide, followed by stirring at 100° C. for 30 minutes. After cooling, the reaction mixture was poured into 150 ml of water. The toluene layer was removed and the aqueous layer was neutralized with glacial acetic acid. The crystals thus precipitated were filtered off. The filtrate was extracted with 200 ml of ethyl acetate, concentrated under reduced pressure and subjected to silica gel column chromatography (Si60 manufactured by Merck; 230-400 mesh; 200 g; eluent: 5% methanol-chloroform (2,000 ml), 10% methanol-chloroform (2,000 ml)). The fraction of 0 to 1,200 ml of 10% methanol-chloroform was distilled under reduced pressure and dried. Thus 0.20 g (1.0 mmol) of N-(2-hydroxy-4-methylphenyl)-N'-(2-hydroxyethyl)urea was obtained as a pale brown solid. The yield was 3%.

1. temperatureAfter cooling
2. customThe toluene layer was removed
3. customThe crystals thus precipitated
4. filtrationwere filtered off
5. extractionThe filtrate was extracted with 200 ml of ethyl acetate
6. concentrationconcentrated under reduced pressure
7. distillationThe fraction of 0 to 1,200 ml of 10% methanol-chloroform was distilled under reduced pressure
8. customdried

ORD record

ord-6c540902771f4d60a5982fe3fe85ccc4

Source dataset

uspto-grants-1994_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05334225