Potassium Phosphate, Tribasic → Indole-3-acetamide

HRID 1741570Notes

Reaction equation

HRID 1741570 reaction equation
P([O-])([O-])([O-])=[O:2].[K+].[K+].[K+].[NH:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([CH2:18][C:19]#[N:20])=[CH:10]1>>[NH:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([CH2:18][C:19]([NH2:20])=[O:2])=[CH:10]1

Participants

3

Reactant 2

HCID 62657Potassium Phosphate, TribasicHCID 351795Indole-3-acetonitrile

Product 1

HCID 397Indole-3-acetamide

Procedure

The suspension of the bacterial cells (corresponding t 25 to 5.92 mg of the dry cells) obtained in Example 8 was added to 4 ml of the reaction solution containing 10 mM of a potassium phosphate buffer (pH 8.0) and 4 M of 3-indoleacetonitrile, and the reaction was conducted at 25° C. After 24 hours from the initiation of the reaction, 4 M (697 g/lit.) of 3-indoleacetamide was produced with a 100% conversion.

Workup

  1. additionThe suspension of the bacterial cells (corresponding t 25 to 5.92 mg of the dry cells)
  2. customobtained in Example 8
  3. customwas conducted at 25° C
  4. customAfter 24 hours from the initiation of the reaction

Sources & evidence

ORD record
ord-c7c6371cd43b434a86e1913050cf5f27
Source dataset
uspto-grants-1994_08
Patent number
US05334519

Reaction notes

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