Water → HCID 131718630, compound

Participants

Reaction Steps

Compound 6 (23.5 g, 0.07 tool) was dissolved in tetrahydrofuran (50 ml). The solution was added dropwise under nitrogen to a stirred suspension of lithium aluminum hydride (3.3 g, 0.0875 mol) in anhydrous ether (100 ml) with cooling in ice. The mixture was stirred at ambient temperature for 15 hrs. The reaction was then cooled in ice and decomposed by carefully adding dropwise water (3.5 ml), 20% sodium hydroxide (2.6 ml) and water (12.3 ml). The mixture was diluted with ether (100 ml) and filtered. The solids were washed with ether. The combined ether solutions were washed with saturated sodium chloride, dried, filtered and concentrated in vacuo to yield 20.3 g 7 (50%) as a pale yellow oil.

Provenance & Evidence