反应详情

A suspension of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine.HCL (2-1) (1.76 g, 0.01 moles) in CH2Cl2 (15 ml) was treated with 2-(N-BOC-4-piperidinyl)ethyl iodide (2--2) (3.73 g, 0.011 moles) followed by 20% NaOH (10 ml) and Aliquot-336 (Aldrich). After stirring for 20 hours the reaction mixture was diluted with CH2Cl2 and the organic phase was separated, washed with brine, dried (Na2SO4) and concentrated. The residue was purified by flash chromatography on silica gel eluting with CHCl3 (98)/MeOH(2) to give pure 2-3.

1. customthe organic phase was separated
2. washwashed with brine
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated
5. customThe residue was purified by flash chromatography on silica gel eluting with CHCl3 (98)/MeOH(2)
6. customto give pure 2-3