反应详情

A solution of 2-3 (3.25 g, 0.0093 moles) in acetone (100 ml) was treated at room temperature with KMnO4 (2.93 g, 0.0185 moles) and the resulting mixture was stirred for 1 hour. The mixture was then filtered (silica gel pad), concentrated and the residue purified by flash chromatography on silica gel eluting with EtOAc (2)/hexanes (3) to give pure 2-4 as an oil.

1. filtrationThe mixture was then filtered (silica gel pad)
2. concentrationconcentrated
3. customthe residue purified by flash chromatography on silica gel eluting with EtOAc (2)/hexanes (3)