Hydrochloric Acid → HCID 54278836, compound

Participants

Reaction Steps

A mixture of 1.5 g methyl 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-5-propenylnicotinate and 3.2 mL of 2N sodium hydroxide in 15 mL methanol is stirred under nitrogen and heated at 45° for 31/2 hours. The reaction is cooled to 10°, acidified to pH 3 with 2N hydrochloric acid, and concentrated in vacuo. The residue is partitioned between methylene chloride and water, and the aqueous phase is further extracted with methylene chloride. The combined organic phases are dried and concentrated in vacuo to a solid. Recrystallization from methylene chloride-hexanes gives a solid, mp 175°-176°.

Provenance & Evidence