Dichromate ion → HCID 19010355, compound

Participants

Reaction Steps

A mixture of 8.2 g of methyl 5-(1-hydroxyethyl)-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinate, 14.5 g of pyridinum dichromate and 1.99 g of pyridinium trifluoroacetate in 30 mL of methylene chloride is stirred at room temperature under nitrogen for 3 days. The reaction mixture is flash-chromatographed through florisil using methylene chloride as eluent, and the combined eluates are washed with water, dried, and concentrated in vacuo to a dark oil. Chromatography of this oil on silica gel using ether-hexane as eluant affords the desired product as a solid. Recrystallization of this solid from methylene chloride-hexane affords a white solid, mp 105°-108° C.

Provenance & Evidence