Acetic Anhydride → HCID 19010354, compound

HRID 1741608Notes

Reaction equation

HRID 1741608 reaction equation
[CH:1]([C:4]1([CH3:21])[C:8](=[O:9])[NH:7][C:6]([C:10]2[N:19]=[C:18]([CH3:20])[CH:17]=[CH:16][C:11]=2[C:12]([O:14][CH3:15])=[O:13])=[N:5]1)([CH3:3])[CH3:2].[C:22](OC(=O)C)(=[O:24])[CH3:23]>>[C:22]([N:7]1[C:8](=[O:9])[C:4]([CH:1]([CH3:3])[CH3:2])([CH3:21])[N:5]=[C:6]1[C:10]1[N:19]=[C:18]([CH3:20])[CH:17]=[CH:16][C:11]=1[C:12]([O:14][CH3:15])=[O:13])(=[O:24])[CH3:23]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 13730884HCID 13730884, compound

Product 1

HCID 19010354HCID 19010354, compound

Procedure

A solution of 33.2 g of methyl 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-6-methylnicotinate in 350 mL of acetic anhydride is stirred and heated at reflux for 4 hours. The solution is concentrated in vacuo, and the residue is triturated with 2:1 hexane-ether to give the desired product as a white solid.

Workup

  1. temperatureheated
  2. temperatureat reflux for 4 hours
  3. concentrationThe solution is concentrated in vacuo
  4. customthe residue is triturated with 2:1 hexane-ether

Sources & evidence

ORD record
ord-6ca21ec42d194f0daf98aed3e5e14ebb
Source dataset
uspto-grants-1994_08
Patent number
US05334576

Reaction notes

Loading…