Water → HCID 19010353, compound

Participants

Reaction Steps

To a solution of 1.0 g of 2-(1-benzoyl-4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-5-bromomethyl-nicotinic acid, methyl ester, in 60 mL ethanol is added 0.24 g sodium cyanide, followed by 10 cc water. The resulting solution is stirred at room temperature for 24 hours and concentrated in vacuo. The residue is partitioned between methylene chloride and water. The aqueous phase is acidified to pH 3 and extracted with methylene chloride, and the combined organic phases are dried and concentrated in vacuo. Chromatography of the residue on silica gel using methylene chloride-methanol mixtures affords the desired product, mp 196°-200° (dec).

Provenance & Evidence