HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazobicycloundecane → 5-Vinyl-2,3-pyridinedicarboxylic acid, dimethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazobicycloundecane | HCID 22171225 | — |
| Reactant | 5-(2-Chloroethyl)-pyridinedicarboxylic acid, dimethyl ester | HCID 86748038 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-Vinyl-2,3-pyridinedicarboxylic acid, dimethyl ester | HCID 86748039 | — |
Reaction Steps
A solution of 2 g of 5-(2-chloroethyl)-pyridine-2,3-dicarboxylic acid, dimethyl ester and 0.13 mL diazobicycloundecane (DBU) in 40 mL of toluene is heated at reflux for 11/2 hours, cooled, and filtered. The filtrate is concentrated in vacuo, and the residue is chromatographed on silica gel using hexane-ethyl acetate mixtures to afford the desired product as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05334576 |
| Source dataset | uspto-grants-1994_08 |
| ORD ID | ord-6b838a6d7e574eea80a189bb9409833e |
| Source note | uspto-grants-1994_08 |