Acetohydroxamic Acid → HCID 19010615, compound

HRID 1741659Notes

Reaction equation

HRID 1741659 reaction equation
[C:1]([NH:4][OH:5])(=[O:3])[CH3:2].Cl[CH:7]([C:9]1[CH:14]=[CH:13][C:12]([S:15][C:16]2[CH:17]=[C:18]([C:23]3([O:29][CH3:30])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[CH:19]=[C:20]([F:22])[CH:21]=2)=[CH:11][CH:10]=1)[CH3:8]>>[C:1]([NH:4][O:5][CH:7]([CH3:8])[C:9]1[CH:14]=[CH:13][C:12]([S:15][C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([C:23]3([O:29][CH3:30])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[CH:17]=2)=[CH:11][CH:10]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 1990Acetohydroxamic AcidHCID 193799314-{3-[4-(1-Chloroethyl)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran

Product 1

HCID 19010615HCID 19010615, compoundYield 62%

Conditions

Temperature
60 °C

Procedure

Using an analogous procedure to that described in Example 1 except that the reactants were heated to 60° C for 2 hours, acetohydroxamic acid was reacted with 4-{3-[4-(1-chloroethyl)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran to give 4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-α-methylbenzyl acetohydroxamate as a gum in 62% yield.

Sources & evidence

ORD record
ord-dd7a13d9348a482fb9aa8b7d0bb77b79
Source dataset
uspto-grants-1994_08
Patent number
US05334614

Reaction notes

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