Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1741660생성일: 2026년 10월 25일
Hydroxyurea → N-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-alpha-methylbenzyloxy}urea
https://huagongshe.com/reaction/1741660
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydroxyurea | HCID 3657 | — |
| 반응물 | 4-{3-[4-(1-Chloroethyl)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran | HCID 19379931 | — |
| 생성물 | N-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-alpha-methylbenzyloxy}urea | HCID 19010619 | 32% |
반응 단계
Using an analogous procedure to that described in Example 1 except that the reactants were heated to 60° C. for 2 hours, hydroxyurea was reacted with 4-{3-[4-(1-chloroethyl)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran to give N-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-α-methylbenzyloxy}urea in 32% yield, m.p. 84°-85° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05334614 |
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| 출처 데이터셋 | uspto-grants-1994_08 |
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| ORD ID | ord-3ec7fa72e62f4c71a83c6466766f01f1 |
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| 출처 메모 | uspto-grants-1994_08 |
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