HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 131718632, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | L-Lactic Acid | HCID 107689 | — |
| Reactant | 3,5-Bis(trifluoromethyl)benzylamine | HCID 521099 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131718632 | HCID 131718632 | — |
Reaction Steps
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (2.5 g) was added to a solution of L-(+)-lactic acid (1.17 g) and 1-hydroxybenzotriazole (1.99 g) in dimethyl formamide (15 ml) at 0° C. under a nitrogen atmosphere. After stirring for 30 mins, 3,5-bistrifluoromethylbenzylamine was added and the solution was stirred at room temperature for 16h. The solution was diluted with dichloromethane (150 ml) and washed with sodium bicarbonate solution, water and brine. After drying (Na2SO4) the solvent was evaporated in vacuo to leave a viscous yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05334606 |
| Source dataset | uspto-grants-1994_08 |
| ORD ID | ord-83da492c3e054cc599af85621f6966db |
| Source note | uspto-grants-1994_08 |