Sodium borohydride → HCID 19010476, compound

Participants

Reaction Steps

A solution of the nitroindole from Step 1 (185 mg, 0.36 mmol) in THF (3 ml) containing NaBH4 /S (200 mg) was heated at reflux for 1 hr. The solvent was removed and the residue was partitioned between EtOAc and H2O. The organic layer was dried, evaporated, and concentrated to give the crude amine (185 mg) which was used directly in the next step.

Provenance & Evidence