HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 9831862, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 2-Methylbenzenesulfonamide | HCID 6924 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 19010466 | HCID 19010466 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 9831862 | HCID 9831862 | 85.7% |
Reaction Steps
To a solution the acid from Step 4 (159 mg) and 2-methylbenzenesulfonamide (70 mg) in CH2Cl2 (3 ml) was added successively 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (78 mg) and DMAP (50 mg). After stirring at r.t. overnight, HOAc (200 μl) was added and the mixture was concentrated. Chromatography of the residue using EtOAc/hexane (2:3) containing 1% HOAc afforded 172 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05334597 |
| Source dataset | uspto-grants-1994_08 |
| ORD ID | ord-fa1e85179edc4b738d30792bf0a6c8a0 |
| Source note | uspto-grants-1994_08 |