Diisobutylaluminum hydride → HCID 6479255, compound

Participants

Reaction Steps

To a solution of (E)-ethyl 3-(2-quinolinyl)-propenoate from Step 1 (2.13 g, 9.40 mmol) in THF (20 ml) at -78° C. was added dropwise a solution of DIBAL (1M in hexane) (3.5 eq). After 10 mins at -78° C., the reaction was quenched with 10 ml of 1M solution of Na+ /K+ tartrate and the mixture was allowed to warm to r.t. It was then processed in the usual manner with EtOAc and H2O. The residue was swished with EtOAc/hexane (1:2) to afford 1.36 g of the title alcohol.

Provenance & Evidence