Trimethylsilyl isocyanate → HCID 18963927, compound

HRID 1741714Notes

Reaction equation

[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][C:13]3[CH:16]=[C:17]([O:20][CH2:21][CH2:22][NH:23][OH:24])[CH:18]=[CH:19][C:12]=3[S:11]2(=[O:26])=[O:25])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[Si]([N:31]=[C:32]=[O:33])(C)C>>[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][C:13]3[CH:16]=[C:17]([O:20][CH2:21][CH2:22][N:23]([C:32]([NH2:31])=[O:33])[OH:24])[CH:18]=[CH:19][C:12]=3[S:11]2(=[O:25])=[O:26])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 70696Trimethylsilyl isocyanate

HCID 18963949HCID 18963949, compound

Product 1

HCID 18963927HCID 18963927, compound

Procedure

Similarly to procedure described in example 1, 2-(3-phenylpropyl)-6-[2-(N-hydroxyamino)-ethoxy]-3,4-dihydro-2H-1,2-benzothiazine-1,1-dioxide is reacted with trimethylsilyl isocyanate to yield 2-(3-phenylpropyl)-6-[2-(N-aminocarbonyl-N-hydroxyamino)-ethoxy]-3,4-dihydro-2H-1,2-benzothiazine-1,1-dioxide, m.p. 134°-135°.

Sources & evidence

ORD record: ord-7ed50a9a12fa400eb394f2a06dc6b34b
Source dataset: uspto-grants-1994_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05334600

Reaction notes

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