Citric Acid → HCID 19010510, compound

Participants

Reaction Steps

A 5N sodium hydroxide solution (0.4 mL) was added to a stirred mixture of the product of Step D (53.5 mg, 0.104 mmol) in methanol (4 mL). A few drops of methylene chloride were added to allow stirring then the mixture was stirred at room temperature for 2 h. The solution volume was reduced to ~10% in vacuo then 5% citric acid solution was added. The mixture was extracted with ethyl acetate (3 times). The combined organic phase was washed with water, brine, dried (magnesium sulfate) and the solvent removed in vacuo. The residue was chromatographed (8, 10% methanol/methylene chloride) to give the titled compound (28.5 mg) as a white solid.

Provenance & Evidence