Citric Acid → HCID 19010495, compound

Participants

Reaction Steps

A 5N sodium hydroxide solution (0.2 mL) was added to a stirred mixture of the product of Step A (27 mg, 0.0524 mmol) in methanol (2 mL). A few drops of methylene chloride were added to allow stirring then the mixture was stirred at room temperature for 2 h. The solution volume was reduced to ~10% in vacuo then 5% citric acid solution added. The mixture was extracted with ethyl acetate (3 times). The combined organic phase was washed with water, brine, dried (magnesium sulfate) and the solvent removed in vacuo. The residue was purified by flash-chromatography using silica gel (8, 10% methanol/methylene chloride) to give the titled compound (12.8 mg) as a white solid.

Provenance & Evidence