Sodium Hydroxide → HCID 19010489, compound

HRID 1741750Notes

Reaction equation

HRID 1741750 reaction equation
[OH-].[Na+].[C:3]([CH:7]([C:32]1[CH:37]=[CH:36][C:35]2[O:38][CH2:39][O:40][C:34]=2[CH:33]=1)[O:8][C:9]1[C:14]([CH2:15][CH2:16][CH3:17])=[CH:13][C:12]([CH2:18][N:19]2[C:23]3[C:24]([Cl:28])=[N:25][CH:26]=[CH:27][C:22]=3[N:21]=[CH:20]2)=[CH:11][C:10]=1[CH2:29][CH2:30][CH3:31])([O:5]C)=[O:4]>CO.C(Cl)Cl>[C:3]([CH:7]([C:32]1[CH:37]=[CH:36][C:35]2[O:38][CH2:39][O:40][C:34]=2[CH:33]=1)[O:8][C:9]1[C:14]([CH2:15][CH2:16][CH3:17])=[CH:13][C:12]([CH2:18][N:19]2[C:23]3[C:24]([Cl:28])=[N:25][CH:26]=[CH:27][C:22]=3[N:21]=[CH:20]2)=[CH:11][C:10]=1[CH2:29][CH2:30][CH3:31])([OH:5])=[O:4]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 19010488HCID 19010488, compound

Product 1

HCID 19010489HCID 19010489, compoundYield 82.2%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneCatalystHCID 887MethanolSolvent

Procedure

A 5N sodium hydroxide solution (0.1 mL) was added to a stirred mixture of the product of Step A (25 mg, 0.0466 mmol) in methanol (1 mL). A few drops of methylene chloride were added to allow stirring then the mixture was stirred at room temperature for 3 h. The solvent was removed in vacuo then 5% citric acid solution added. The precipitate was filtered off, washed with water and dried in vacuo to give the titled compound (20 mg).

Workup

  1. stirringthe mixture was stirred at room temperature for 3 h
  2. customThe solvent was removed in vacuo
  3. addition5% citric acid solution added
  4. filtrationThe precipitate was filtered off
  5. washwashed with water
  6. customdried in vacuo

Sources & evidence

ORD record
ord-b09d9ccf0fc1443caaaeb0bef2aabc8c
Source dataset
uspto-grants-1994_08
Patent number
US05334598

Reaction notes

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