Thionyl Chloride → HCID 15224690, compound

Participants

Reaction Steps

To a stirred suspension of 28 g (0.1 mol) of the product of step (a) in 150 mL of benzene at 10° C. was added dropwise a solution of 16 mL (1.63 mol) of thionyl chloride in 150 mL of benzene. The mixture was allowed to warm to ambient temperature, stirred overnight and concentrated to dryness. Fresh benzene was added and the solution reconcentrated several more times to give 27 g of crude 1-(chloromethyl)-5,5-diphenyl-2-piperidinone as a white solid.

Provenance & Evidence