2-Thiazoline → (2-((Dimethylamino)methyl)thiazol-4-yl)methanol

HRID 1741788Notes

Reaction equation

HRID 1741788 reaction equation
O[C:2]1([CH2:11]Cl)[CH2:6][S:5][C:4]([CH2:7][N:8]([CH3:10])[CH3:9])=[N:3]1.C[O-:14].[K+].S1CCN=C1>CO>[CH3:9][N:8]([CH2:7][C:4]1[S:5][CH:6]=[C:2]([CH2:11][OH:14])[N:3]=1)[CH3:10]

Participants

5

Reactant 3

HCID 1202692-ThiazolineHCID 103307024-Thiazolol, 4-(chloromethyl)-2-[(dimethylamino)methyl]-4,5-dihydro-HCID 23664618Potassium methoxide

Product 1

HCID 1838020(2-((Dimethylamino)methyl)thiazol-4-yl)methanol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The process of Example 5 was repeated using 3.0 g (0.014 mol) of 4-hydroxy-4-chloromethyl-2-(dimethylaminomethyl)thiazoline (prepared as in Example 1), 48 ml of methanol and 0.98 g (0.014 mol) of potassium methoxide. The HPLC assay set forth in Example 3 indicated that 70.1% of the thiazoline substrate had converted to the desired titled product.

Sources & evidence

ORD record
ord-003ee34ce41e478b97d85c8788c10a14
Source dataset
uspto-grants-1994_08
Patent number
US05334725

Reaction notes

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