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To a mixture of ethyl 4-[1-(4-methoxybenzoyl)-indolizin-3-yl]butyrate (640 mg) and ethanethiol (2.5 ml) in dichloromethane (8 ml) was added aluminum chloride (700 mg) at 0° C. After stirred at 0° C. for 10 minutes, the solvent was evaporated and the residue was poured into a mixture of ethyl acetate and ice-water. The organic layer was separated, washed with aqueous sodium bicarbonate and brine, dried over magnesium sulfate and evaporated. The residue was chromatographed on silica gel column eluting with a mixture of chloroform and ethyl acetate (4:1) to give ethyl 4-[1-(4-hydroxybenzoyl)indolizin-3-yl]butyrate (344 mg) as yellow solid.

1. customthe solvent was evaporated
2. additionthe residue was poured into a mixture of ethyl acetate and ice-water
3. customThe organic layer was separated
4. washwashed with aqueous sodium bicarbonate and brine
5. dry with materialdried over magnesium sulfate
6. customevaporated
7. customThe residue was chromatographed on silica gel column
8. washeluting with a mixture of chloroform and ethyl acetate (4:1)