反应详情

To a solution of ethyl 5-(2-pyridyl)pentanoate (1.07 g) in acetone (5 ml) was added bromoacetone (0.51 ml) and the mixture was refluxed for 2 hours. After removal of the solvent, the residue was dissolved in aqueous sodium bicarbonate (1 g sodium bicarbonate/20 ml water) and then refluxed for 30 minutes. The mixture was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate, evaporated in vacuo, and chromatographed on silica gel (dichloromethane) to give ethyl 4-(2-methylindolizin-1-yl)butyrate (778 mg).

1. temperaturethe mixture was refluxed for 2 hours
2. customAfter removal of the solvent
3. dissolutionthe residue was dissolved in aqueous sodium bicarbonate (1 g sodium bicarbonate/20 ml water)
4. temperaturerefluxed for 30 minutes
5. extractionThe mixture was extracted with ethyl acetate
6. washThe combined organic layers were washed with brine
7. dry with materialdried over sodium sulfate
8. customevaporated in vacuo
9. customchromatographed on silica gel (dichloromethane)