Dimethylformamide → p-Acetoxybenzoyl chloride

Participants

Reaction Steps

N,N-Dimethylformamide (0.5 ml) was added to a solution of 4-acetoxybenzoic acid (50 g) and oxalyl chloride (27 ml) in dichloromethane (500 ml). The mixture was stirred for 2 hours at room temperature. The solvent was evaporated and the residue was dissolved in n-hexane (200 ml). After filtration, the solution was evaporated to give 4-acetoxybenzoyl chloride as a yellow oil (55.1 g).

Provenance & Evidence