HCID 19010789, compound → HCID 19010734, compound

HRID 1741829Notes

Reaction equation

HRID 1741829 reaction equation
C([O:8][C:9]([CH:11]([NH:13][C:14]1[CH:15]=[C:16]([CH:36]=[CH:37][CH:38]=1)[C:17]([C:19]1[CH:20]=[C:21]([CH2:28][CH2:29][CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32])[N:22]2[C:27]=1[CH:26]=[CH:25][CH:24]=[CH:23]2)=[O:18])[CH3:12])=[O:10])C1C=CC=CC=1>C(O)C.[Pd]>[C:9]([CH:11]([NH:13][C:14]1[CH:15]=[C:16]([CH:36]=[CH:37][CH:38]=1)[C:17]([C:19]1[CH:20]=[C:21]([CH2:28][CH2:29][CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32])[N:22]2[C:27]=1[CH:26]=[CH:25][CH:24]=[CH:23]2)=[O:18])[CH3:12])([OH:10])=[O:8]

Participants

4

Reactant 1

HCID 19010789HCID 19010789, compound

Product 1

HCID 19010734HCID 19010734, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of ethyl 4-[1-[3-[(1-benzyloxycarbonylethyl)amino]benzoyl]indolizin-3-yl]butyrate (0.20 g) in ethanol (10 ml) was added 10% palladium on carbon (0.1 g). The mixture was stirred under hydrogen atmosphere at room temperature for 2 hours. Removal of catalyst and evaporation of solvent gave ethyl 4-[1-[3-(1-carboxyethylamino)benzoyl]indolizin-3-yl]butyrate (0.15 g) as yellow powder.

Workup

  1. customRemoval of catalyst and evaporation of solvent

Sources & evidence

ORD record
ord-d8391d546839479cbc67be1a04bc88b9
Source dataset
uspto-grants-1994_08
Patent number
US05334716

Reaction notes

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