HCID 19010782, compound → HCID 19010799, compound

Participants

Reaction Steps

A mixture of 1-[3-fluoro-4-(2-methyl-1-propenyl)phenyl]pentanol (300 mg) and 10% palladium on carbon (90 mg) in methanol (10 ml) was stirred under hydrogen atmosphere for 30 minutes at room temperature. Catalyst was removed by filtration and the solvent was evaporated. The residue was chromatographed on silica gel column eluting with a mixture of hexane and ethyl acetate (85:15) to give 1-(3-fluoro-4-isobutylphenyl)pentanol (167 mg) as an oil.

Provenance & Evidence