反应详情

To a solution of ethyl 4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]-butyrate (279 mg) in ethanol (10 ml) was added 4N sodium hydroxide (0.44 ml). Stirring was continued for 1 hour at 40° C. The reaction mixture was evaporated in vacuo, then added a solution of potassium dihydrogen phosphate (300 mg) in water and 1N hydrochloric acid (26 ml), and extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate. After evaporation of the solvent, the residue was chromatographed on silica gel eluting with ethyl acetate to give 4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]butyric acid (229 mg).

1. customThe reaction mixture was evaporated in vacuo
2. additionadded a solution of potassium dihydrogen phosphate (300 mg) in water and 1N hydrochloric acid (26 ml)
3. extractionextracted with ethyl acetate
4. dry with materialThe combined organic layers were dried over sodium sulfate
5. customAfter evaporation of the solvent
6. customthe residue was chromatographed on silica gel eluting with ethyl acetate