HRID1741851

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：CC(C)Cc1ccc(C(Nc2cccc(C(=O)c3cc(CCCC(=O)O)n4ccccc34)c2)c2ccc(CC(C)C)cc2)cc1

HCID11734695

未命名化合物

PRODUCTS

生成物

结构：CC(C)Cc1ccc(C(Nc2cccc(C(=O)c3cc(CCCC(=O)[O-])n4ccccc34)c2)c2ccc(CC(C)C)cc2)cc1.[Na+]

HCID23719344

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

To a solution of 4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]butyric acid (244 mg) in ethanol was added 1N sodium hydroxide. After removal of the solvent, the residue was dissolved in benzene, filtered through a cotton filter, and evaporated in vacuo to give sodium 4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]butyrate (240 mg).

WORKUP

后处理

customAfter removal of the solvent
dissolutionthe residue was dissolved in benzene
filtrationfiltered through a cotton
filtrationfilter
customevaporated in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-99d8c044e2fa451eb7c40d39ed9f635b
来源数据集: uspto-grants-1994_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05334716
来源说明: uspto-grants-1994_08

反应 SMILES

[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]([NH:22][C:23]2[CH:24]=[C:25]([CH:43]=[CH:44][CH:45]=2)[C:26]([C:28]2[CH:29]=[C:30]([CH2:37][CH2:38][CH2:39][C:40]([OH:42])=[O:41])[N:31]3[C:36]=2[CH:35]=[CH:34][CH:33]=[CH:32]3)=[O:27])[C:12]2[CH:17]=[CH:16][C:15]([CH2:18][CH:19]([CH3:21])[CH3:20])=[CH:14][CH:13]=2)=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].[OH-].[Na+:47]>C(O)C>[CH2:18]([C:15]1[CH:14]=[CH:13][C:12]([CH:11]([NH:22][C:23]2[CH:24]=[C:25]([CH:43]=[CH:44][CH:45]=2)[C:26]([C:28]2[CH:29]=[C:30]([CH2:37][CH2:38][CH2:39][C:40]([O-:42])=[O:41])[N:31]3[C:36]=2[CH:35]=[CH:34][CH:33]=[CH:32]3)=[O:27])[C:8]2[CH:7]=[CH:6][C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])=[CH:10][CH:9]=2)=[CH:17][CH:16]=1)[CH:19]([CH3:20])[CH3:21].[Na+:47]