1-Heptanamine → HCID 19010763, compound

Participants

Reaction Steps

To a solution of ethyl 4- [1- [3- [(1-carboxyethyl)amino]benzoyl]indolizin-3-yl]butyrate (60 mg), heptylamine (16 mg) and 1-hydroxybenzotriazole (20 mg) in dichloromethane (3 ml) was added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (30 mg). The mixture was stirred for 3 hours at room temperature, evaporated and dissolved in ethyl acetate (10 ml). The solution was washed with diluted hydrochloric acid and water and dried over magnesium sulfate. The solvent was removed under reduced pressure to give ethyl 4-[1-[3-[[1(heptylcarbamoyl)ethyl]amino]benzoyl]indolizin-3-yl]butyrate (70 mg) as a yellow oil.

Provenance & Evidence