Hydrochloric Acid → 3-(3-Fluorophenyl)-4-ethyl-1,2,4-triazolin-5-one

HRID 1741863Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1741863
[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[C:5]([NH:7][NH:8][C:9]([NH:11][CH2:12][CH3:13])=[O:10])=O.Cl>[OH-].[Na+]>[F:1][C:2]1[CH:3]=[C:4]([CH:5]2[N:11]([CH2:12][CH3:13])[C:9](=[O:10])[N:8]=[N:7]2)[CH:14]=[CH:15][CH:16]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 190109271-(3-Fluorobenzoyl)-4-ethyl semicarbazide

Produkt 1

HCID 678503063-(3-Fluorophenyl)-4-ethyl-1,2,4-triazolin-5-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

A mixture of the 1-(3-fluorobenzoyl)-4-ethyl semicarbazide and 1N NaOH solution (100 mL) was refluxed for 20 hr, cooled to room temperature and neutrallized with conc. HCl. The suspension was extracted with ethyl acetate and the organic layer was dried over MgSO4. Removal of the solvent in vacuo yielded 7.3 g of 3-(3-fluorophenyl)-4-ethyl-1,2,4-triazolin-5-one as a white solid. mp 135°-140° C.

Aufarbeitung

  1. temperaturewas refluxed for 20 hr
  2. extractionThe suspension was extracted with ethyl acetate
  3. dry with materialthe organic layer was dried over MgSO4
  4. customRemoval of the solvent in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3d26e162fb0b4535b26da384713480f7
Quelldatensatz
uspto-grants-1994_08
Patentnummer
US05334726

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