Sulfuric Acid → 4,5-(Dimethylmethylenedioxy)-3-methoxymethoxy-6-heptenal

Participants

Reaction Conditions

Reaction Steps

4,5-(Dimethylmethylenedioxy)-3-methoxymethoxy-6-heptenenitrile (159.8 mg) was dissolved in dry toluene, and 1.6 ml of 0.5N diisopropyl aluminum hydride was added at -78° C. The reaction mixture was stirred at -78° C. for 2 hours and at -40° C. for 30 minutes, and 5% dilute sulfuric acid was gradually added at 0° C. The reaction mixture was diluted with diethyl ether, and the organic layer was washed with a sodium chloride aqueous solution, dried over anhydrous magnesium sulfate, concentrated under reduced pressure to afford 91.1 mg of 4,5-(dimethylmethylenedioxy)-3-methoxymethoxy-6-heptenal.

Provenance & Evidence