Dimethyl Sulfide → HCID 53660136, compound

Participants

Reaction Conditions

Reaction Steps

N-chlorosuccinimide (140 mg) was suspended in 10 ml of methylene chloride, and 74 mg of dimethyl sulfide was added at 0° C. The mixture was stirred, and cooled to -25° C. A solution of 958 mg of (4-(3-tert-butyldiphenylsilyloxypropoxy)-3,5-bis-(tert -butyldiphenylsilyloxy)-2-methylenecyclohexylidene) ethanol in 2 ml of methylene chloride was added dropwise, followed by stirring at 0° C. for 2 hours. A sodium chloride aqueous solution was added to the reaction mixture, and extraction was conducted with diethyl ether. The extract was washed with a sodium chloride aqueous solution, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. There resulted 931 mg of (4-(3-tert-butyldiphenylsilyloxypropoxy)-3,5-bis-(tert-butyldiphenylsilyloxy)-2-methylenecyclohexylidene)ethyl chloride.

Provenance & Evidence