Pyridine → HCID 54264787, compound

Participants

Reaction Steps

About 5 ml of the solvent mixture benzene/DMSO (1:1) are introduced into a two-neck flask which has been flame-treated and flushed with nitrogen, and 1 mmol of absolute pyridine and 0.5 mmol of CF3COOH, and 1 mmol of 1 and 3 mmol of dicyclohexylcarbodiimide (DCCI), dissolved in benzene/DMSO, are added with stirring. The mixture is stirred overnight at room temperature. Precipitated dicyclohexylurea is filtered off, and the solution is evaporated on a rotary evaporator. DMSO is removed by repeated shaking with water and, if necessary, at 40° C. in a bulb tube. The crude product is filtered again and purified by flash chromatography (PE/CH2Cl2).

Provenance & Evidence