HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 67736326, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Phosphorochloridic acid, dimethyl ester | HCID 101863 | — |
| Reactant | Florfenicol amine | HCID 156406 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | HCID 67736326 | HCID 67736326 | — |
Reaction Steps
Dimethylchlorophosphate (1.44 g; 10 mmol) dissolved in dichloromethane (4 ml) was slowly added dropwise to a mixture cooled to 0° C. of (1R,2 S)-2-amino-3-fluoro-1-(4-methylsulfonylphenyl)-1-propanol (2.47 g; 10 mmol) in acetonitrile (15 ml) and dichloroethane (15 ml) containing triethylamine (1.39 ml; 10 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05336664 |
| Source dataset | uspto-grants-1994_08 |
| ORD ID | ord-f22a1df6db9f4449b49bace000a923c9 |
| Source note | uspto-grants-1994_08 |