HCID 54254236, compound → 2-Chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]benzaldehyde

Participants

Reaction Steps

A solution of 20.08 g of 2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl] benzyl alcohol in 250 ml dichloromethane is added dropwise in the course of 30 minutes with stirring at room temperature to a suspension of 19.38 g of pyridinium chlorochromate in 250 ml of dichloromethane, and stirring of the reaction mixture is continued for 3 hours at 25°-28° C. The clear solution is decanted, the brown residue is washed with 100 ml of dichloromethane, and the dichloromethane solution is filtered through 150 g of silica gel. The filtrate is concentrated, and the residue is recrystallised from n-hexane/ethyl acetate; m.p.: 168°-169° C.

Provenance & Evidence