HCID 19429288, compound → HCID 19429294, compound

Ethyl 1-methyl-5,6-dihydroimidazo[1,5-a]pyridine-7-carboxylate (0.90 g) was subjected to catalytic reduction in 30 ml methanol at room temperature for ten hours by using 0.02 g of 5% paradium-carbon as the catalyst. The reaction mixture was filtered, the filtrate was concentrated to dryness under reduced pressure, ethyl acetate was added to the residue, and the resulting mixture was extracted with 0.5N-HCl. The aqueous layer collected was alkalized by addition of potassium carbonate and then extracted with dichloromethane, the organic layer collected was washed with saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure, thus giving 0.89 g (98 %) of ethyl 1-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine-7-carboxylate.

1. filtrationThe reaction mixture was filtered
2. concentrationthe filtrate was concentrated to dryness under reduced pressure, ethyl acetate
3. additionwas added to the residue
4. extractionthe resulting mixture was extracted with 0.5N-HCl
5. customThe aqueous layer collected
6. additionwas alkalized by addition of potassium carbonate
7. extractionextracted with dichloromethane
8. customthe organic layer collected
9. washwas washed with saturated aqueous solution of sodium chloride
10. dry with materialdried over anhydrous sodium sulfate
11. concentrationconcentrated under reduced pressure

ORD record

ord-b35a5af848d14a2d85c8a10c20d39b50

Source dataset

uspto-grants-1994_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05336679