Trifluoroacetamidine → HCID 136088685, compound

Participants

Reaction Steps

Ethyl 2-acetylpentanoic acid (17.2 g, 0.1 mol) in absolute EtOH was treated with 2.3 g, 0.1 mol) sodium until the metal was dissolved. Trifluoroacetamidine (11.5 g, 0.1 mol) was added and the mixture was refluxed for 3 h, then evaporated to dryness. The residue was taken up in H2O, acidified with 2N HCl, and extracted with EtOAc. The organic layer was washed with water (twice), dried, and evaporated to give an oil. Purification by flash chromatography (CH2Cl2, CH2Cl2 -EtOAc 5%) afforded 7.5 g (34%) of the desired compound as crystals.

Provenance & Evidence