N,N-Dimethylaniline → 4-Chloro-2-methyl-6-(trifluoromethyl)pyrimidine

Participants

Reaction Steps

2-Methyl-6-trifluoromethyl-4H-pyrimidin-4-one of Example 4 (2.00 g, 11.2 mmol) was mixed with phosphorus oxychloride (10 mL) and N,N-dimethylaniline (2 mL), and refluxed for 3 h. The dark solution was poured into crushed ice and extracted with Et2O. The organic layer was washed with H2O (twice), dried over Na2SO4, then evaporated to dryness to afford 2.00 g (91%) of an oil.

Provenance & Evidence