反应详情

A solution of methanol (10.2 mL, 252 mmoles) in 15 mL toluene was added dropwise to a solution of chlorosulfonyl isocyanate (22.0 mL, 252 mmoles) in 75 mL toluene at 0° C. The cooling bath was removed and stirred for one-half hour at room temperature. This was then cooled to 0° C. and 65 mL ice cold hexanes was added. The white precipitate was collected by filtration and washed 2 times with a small amount of cold hexane to give 33.0 g of a white solid, mp 72°-74° C.

1. customThe cooling bath was removed
2. temperatureThis was then cooled to 0° C.
3. addition65 mL ice cold hexanes was added
4. filtrationThe white precipitate was collected by filtration
5. washwashed 2 times with a small amount of cold hexane