HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1742049Generated: October 29, 2026
1-Hydroxybenzotriazole hydrate → benzhydryl (6R,7R)-3-(chloromethyl)-7-[[(2Z)-2-methoxyimino-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
https://huagongshe.com/reaction/1742049
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| Reactant | (Z)-2-methoxymino-2-(2-(tritylamino)thiazol-4-yl)acetic acid | HCID 5928144 | — |
| Reactant | 7-Amino-3-chloromethyl-3-cephem-4-carboxylic acid diphenylmethyl ester hydrochloride | HCID 13239628 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | benzhydryl (6R,7R)-3-(chloromethyl)-7-[[(2Z)-2-methoxyimino-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | HCID 13239632 | — |
Reaction Steps
To 25 ml of N,N-dimethylformamide were added 1.3 g (3 mmol) of (Z)-2-(2-tritylaminothiazol-4-yl)-2-methoxyiminoacetic acid and 1.35 (3 mmol) of diphenylmethyl 7 β-amino-3-chloromethyl-ceph-3-em-4-carboxylate hydrochloride. The mixture was cooled to 0° C., and 0.53 g (3.9 mmol) of N-hydroxybenzotriazole hydrate and then 0.80 g (3.9 mmol) of N,N-dicyclohexylcarbodiimide were added thereto.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05336673 |
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| Source dataset | uspto-grants-1994_08 |
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| ORD ID | ord-c447f676c2e840b3a0369aa4a83f7d86 |
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| Source note | uspto-grants-1994_08 |
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