HuagongsheHuagongshe Chemistry Print Report · For research reference only
Salicylaldehyde → 4-Methoxybenzyl 7 beta-(2-hydroxybenzylideneamino)-3-chloromethyl-ceph-3-em-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Salicylaldehyde | HCID 6998 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-methoxybenzyl (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride (1:1) | HCID 14032024 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Methoxybenzyl 7 beta-(2-hydroxybenzylideneamino)-3-chloromethyl-ceph-3-em-4-carboxylate | HCID 136614160 | 90.1% |
Reaction Steps
In 50 ml of methanol was dissolved 4.05 g(10 mmol) of 4-methoxybenzyl 7 β-amino-3-chloromethyl-ceph-3-em-4-carboxylate hydrochloride, and 1.28 ml(12 mmol) of salicylaldehyde and 1.39 ml(10 mmol) of triethylamine were added thereto. The reaction mixture was stirred for 5 hours. The resulting precipitate was filtered, washed with 50 ml of methanol and dried to give 4.26 g of the desired compound(90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05336673 |
| Source dataset | uspto-grants-1994_08 |
| ORD ID | ord-fb3e1e6c7aa7480ca0a82dd33d70dbdf |
| Source note | uspto-grants-1994_08 |