Cyclopentanecarboxylic acid → HCID 21760921, compound

Participants

Reaction Steps

Compound k obtained in Reference Example 2 (10.8 g, 35.3 mmol) was dissolved in a mixture of 100 ml of dioxane and 100 ml of water, and 3.86 ml (35.5 mmol) of cyclopentanecarboxylic acid was added to the solution. Then, 1-ethyl-3-(3-dimethylamino)propylcarbodiimide hydrochloride (11.2 g, 56.8 mmol) was added slowly at room temperature at pH 5-6 over a period of five minutes. The crystals formed were collected by filtration to give 7.13 g (yield: 41%) of 6-amino-1-[4-(cyclopentanecarbonylamino)phenethyl]-5-(cyclopentanecarbonyl) amino-3-propyluracil (Compound x) as white powder.

Provenance & Evidence