HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propyl isocyanate → 1-(4-Nitrophenethyl)-3-propylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propyl isocyanate | HCID 61033 | — |
| Reactant | 4-Nitrophenethylamine | HCID 95153 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(4-Nitrophenethyl)-3-propylurea | HCID 11694493 | 89.8% |
Reaction Steps
4-Nitrophenethylamine (127 g, 0.767 mol) [J. Org. Chem., 43, 31 (1978)] was dissolved in 2.5 liters of toluene, and propyl isocyanate (72 ml, 0.764 mol) was slowly added dropwise at room temperature. The mixture was stirred for two hours, and the crystals formed were collected by filtration and dried under reduced pressure to give 171.5 g (yield: 89.8%) of 1-(4-nitrophenethyl)-3propylurea (Compound a).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05336769 |
| Source dataset | uspto-grants-1994_08 |
| ORD ID | ord-0ffbfc6b4d1441bcb6b9b80ef6c3f77e |
| Source note | uspto-grants-1994_08 |