Acetic Anhydride → HCID 57256928, compound

HRID 1742069Notes

Reaction equation

[NH2:1][C:2]1[N:6]([C:7](=[N:21][O:22][S:23]([C:26]2[CH:32]=[CH:31][C:29]([CH3:30])=[CH:28][CH:27]=2)(=[O:25])=[O:24])[CH2:8][CH2:9][N:10]2[C:14](=[O:15])[C:13]3=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]3[C:11]2=[O:20])[N:5]=[C:4]([C:33]([CH3:36])([CH3:35])[CH3:34])[CH:3]=1.[CH3:37][C:38](OC(C)=O)=[O:39]>>[C:38]([NH:1][C:2]1[N:6]([C:7](=[N:21][O:22][S:23]([C:26]2[CH:27]=[CH:28][C:29]([CH3:30])=[CH:31][CH:32]=2)(=[O:25])=[O:24])[CH2:8][CH2:9][N:10]2[C:14](=[O:15])[C:13]3=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]3[C:11]2=[O:20])[N:5]=[C:4]([C:33]([CH3:36])([CH3:35])[CH3:34])[CH:3]=1)(=[O:39])[CH3:37]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 56997615HCID 56997615, compound

Product 1

HCID 57256928HCID 57256928, compoundYield 59%

Procedure

4.39 g (8.6 mmol) of 5-amino-3-tert.butyl-1-(3-phthalimido-O-tosyl-propanehydroximoyl)pyrazole are reacted with acetanhydride in the same way as in example 1, synthesis step 3. The crude product which is obtained is recrystallised from methanol. 2.8 g (59%) of 5-acetamido-3-tert.butyl-1-(3-phthalimido-O-tosyl-propanehydroximoyl)-pyrazole with a m. pt. of 195°-201° C. are obtained.

Workup

customThe crude product which is obtained
customis recrystallised from methanol

Sources & evidence

ORD record: ord-1f4d3cb8491849b288a05c560a56edcc
Source dataset: uspto-grants-1994_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05336780

Reaction notes

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